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Article

Is hyperhomocysteinemia a causal factor for heart failure? The impact of the functional variants of MTHFR and PON1 on ischemic and non-ischemic etiology.

International journal of cardiology - 1 Feb 2017

Strauss Ewa, Supinski Wieslaw, Radziemski Artur, Oszkinis Grzegorz, Pawlak Andrzej Leon, Gluszek Jerzy

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia was found to be uniformly associated with the development of heart failure (HF) and HF mortality; however, it is uncertain whether this relation is causative or not. We used Mendelian randomization to examine the associations of the methylene tetrahydrofolate gene (MTHFR) and paraoxonase 1 gene (PON1) variants as a proxy for lifelong exposure to high Hcy and Hcy-thiolactone...

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Source

Identifiers

PMID: 27863359
DOI: 10.1016/j.ijcard.2016.11.213

Genes

PON1
MTHFR
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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