Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.

doi:10.1016/j.cccn.2004.12.002

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Article

Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2005

Helfenstein Tatiana, Fonseca Francisco A H, Relvas Waldir G M, Santos Andreza O, Dabela Maria L, Matheus Simone C P, D'Almeida Vânia, Tufik Sérgio, Souza Fernanda G, Rodrigues Paula R, Taglieri Rosely, Sousa Eder F, Izar Maria C O

Abstract excerpt

BACKGROUND: Hyperhomocysteinemia has emerged as a novel risk factor for myocardial infarction (MI). Some mechanisms proposed to explain its relationship with coronary events are also shared by major coronary risk factors. We examined whether C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms could affect the relative risk for MI. METHODS: A sample of 196 individuals was divided...

Topics

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Adult
Aged
Case-Control Studies
Diabetes Mellitus, Type 2
Female
Homocysteine
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hyperhomocysteinemia

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Myocardial Infarction

Polymorphism, Single Nucleotide

Regression Analysis

Source

Open in PubMed

Identifiers

PMID: 15820491
DOI: 10.1016/j.cccn.2004.12.002

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