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CTH G1208T and MTHFR A1298C polymorphisms are associated with a higher risk of a first myocardial infarction with fatal outcome among women.

Drug metabolism and personalized therapy - 1 Mar 2023

Söderström Elisabet, Andersson Jonas, Söderberg Stefan, van Guelpen Bethany, Nilsson Torbjörn K, Hultdin Johan

Abstract excerpt

OBJECTIVES: Cystathionine-gamma-lyase (CSE) in the transsulfuration pathway generates hydrogen sulfide (H2S), suggested regulating cardiovascular function. The G1208T polymorphism in the CTH gene, rs1021737, has, in addition to MTHFR, been found to increase homocysteine, related to myocardial infarction (MI) risk. This study aimed, for the first time, to investigate the associations of the polymorphisms CTH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36279151
DOI: 10.1515/dmpt-2022-0119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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