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Article

Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon.

Stem cells (Dayton, Ohio) - 1 Mar 2017

Agarwal Shailesh, Loder Shawn J, Cholok David, Peterson Joshua, Li John, Breuler Christopher, Cameron Brownley R, Hsin Sung Hsiao, Chung Michael T, Kamiya Nobuhiro, Li Shuli, Zhao Bin, Kaartinen Vesa, Davis Thomas A, Qureshi Ammar T, Schipani Ernestina, Mishina Yuji, Levi Benjamin

Abstract excerpt

The pathologic development of heterotopic ossification (HO) is well described in patients with extensive trauma or with hyperactivating mutations of the bone morphogenetic protein (BMP) receptor ACVR1. However, identification of progenitor cells contributing to this process remains elusive. Here we show that connective tissue cells contribute to a substantial amount of HO anlagen caused by trauma using postnatal,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27862618
DOI: 10.1002/stem.2515
PMCID: PMC5529170

Genes

ACVR1
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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