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Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles

25 Feb 2022

Abstract excerpt

Abstract The cells of origin of neurogenic heterotopic ossifications (NHOs), which develop frequently in the periarticular muscles following spinal cord injuries (SCIs) and traumatic brain injuries, remain unclear because skeletal muscle harbors two progenitor cell populations: satellite cells (SCs), which are myogenic, and fibroadipogenic progenitors (FAPs), which are mesenchymal. Lineage-tracing experiments...

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PMID: 35217633
DOI: 10.1038/s41413-022-00188-y

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