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Article

Cell autonomous TGFβ signaling is essential for stem/progenitor cell recruitment into degenerative tendons.

Stem cell reports - 14 Dec 2021

Tan Guak-Kim, Pryce Brian A, Stabio Anna, Keene Douglas R, Tufa Sara F, Schweitzer Ronen

Abstract excerpt

Understanding cell recruitment in damaged tendons is critical for improvements in regenerative therapy. We recently reported that targeted disruption of transforming growth factor beta (TGFβ) type II receptor in the tendon cell lineage (Tgfbr2ScxCre) resulted in resident tenocyte dedifferentiation and tendon deterioration in postnatal stages. Here we extend the analysis and identify direct recruitment of...

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Identifiers

PMID: 34822771
DOI: 10.1016/j.stemcr.2021.10.018
PMCID: PMC8693658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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