Article
The linkage method: a novel approach for SNP detection and haplotype reconstruction from a single diploid individual using next-generation sequence data.
Molecular biology and evolution - 1 Sept 2013
Sasaki Eriko, Sugino Ryuichi P, Innan Hideki
Abstract excerpt
When we sequence a diploid individual, the output actually comprises two genomes: one from the paternal parent and the other from the maternal parent. In this study, we introduce a novel heuristic algorithm for distinguishing single-nucleotide polymorphisms (SNPs) from the two parents and phasing...
Topics
- Algorithms
- Alleles
- Animals
- Base Sequence
- Diploidy
- Drosophila melanogaster
- Genetic Linkage
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Molecular Sequence Data
- Mutation Rate
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA
- Software