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Article

Genetic polymorphisms of CYP3A4 among Chinese patients with steroid-induced osteonecrosis of the femoral head.

Medicine - 1 Nov 2016

Wang Yuan, Li Xiuling, Gao Yaoyu, Li Zhi, Yu Lidong, Meng Qingbo, Sun Li, Wang Jianzhong

Abstract excerpt

BACKGROUND: Steroid therapy has been an important reason of nontraumatic osteonecrosis of the femoral head (ONFH). Steroids are metabolized by hepatic cytochrome P4503A, a low endogenous activity of this enzyme can contribute to the pathogenesis of ONFH. The aim of this study was to investigate the associations of polymorphisms of cytochrome P4503A4 (CYP3A4) gene with steroid-induced ONFH in Chinese patients....

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Source

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Identifiers

PMID: 27858915
DOI: 10.1097/MD.0000000000005332
PMCID: PMC5591163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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