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Article

Integrative analyses of genes related to femoral head osteonecrosis: an umbrella review of systematic reviews and meta-analyses of observational studies.

Journal of orthopaedic surgery and research - 28 Mar 2022

Lee Sangyeob, Yoo Jun-Il, Kang Yang-Jae

Abstract excerpt

BACKGROUND: Femoral head osteonecrosis (FHON) is a worldwide challenging clinical topic. Steroid use is one of the main etiologies of FHON. There are several genetic variants associated with FHON. Therefore, the purpose of this umbrella review was to provide a comprehensive summary of a meta-analysis and systematic review of genetic variations associated with nonsteroidal and steroid-induced FHON. METHODS: The...

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Identifiers

PMID: 35346283
DOI: 10.1186/s13018-022-03079-4
PMCID: PMC8961967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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