Article
Genetically decreased vitamin D and risk of Alzheimer disease.
Neurology - 13 Dec 2016
Mokry Lauren E, Ross Stephanie, Morris John A, Manousaki Despoina, Forgetta Vincenzo, Richards J Brent
Abstract excerpt
OBJECTIVE: To test whether genetically decreased vitamin D levels are associated with Alzheimer disease (AD) using mendelian randomization (MR), a method that minimizes bias due to confounding or reverse causation. METHODS: We selected single nucleotide polymorphisms (SNPs) that are strongly associated with 25-hydroxyvitamin D (25OHD) levels (p < 5 × 10-8) from the Study of Underlying Genetic Determinants of...
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