Article
Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes.
Blood - 26 Jan 2017
Chesnais Virginie, Arcangeli Marie-Laure, Delette Caroline, Rousseau Alice, Guermouche Hélène, Lefevre Carine, Bondu Sabrina, Diop M'boyba, Cheok Meyling, Chapuis Nicolas, Legros Laurence, Raynaud Sophie, Willems Lise, Bouscary Didier, Lauret Evelyne, Bernard Olivier A, Kosmider Olivier, Pflumio Françoise, Fontenay Michaela
Abstract excerpt
Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders in which recurrent mutations define clonal hematopoiesis. The origin of the phenotypic diversity of non-del(5q) MDS remains unclear. Here, we investigated the clonal architecture of the CD34+CD38- hematopoietic stem/progenitor cell (HSPC) compartment and interrogated dominant clones for MDS-initiating cells. We found that clones mainly...
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