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Article

p15 Expression Differentiates Nevus from Melanoma.

The American journal of pathology - 1 Dec 2016

Taylor Laura A, O'Day Conor, Dentchev Tzvete, Hood Kyle, Chu Emily Y, Ridky Todd W, Seykora John T

Abstract excerpt

Most melanomas are driven by BRAF(V600E)-activating mutations, while nevi harboring the same mutations have growth arrest. Although decreased p16 expression has been associated with melanoma formation, in recent work, p15 represented a primary effector of oncogene-induced senescence in nevomelanocytes that was diminished in melanomas. This study determined whether decreased p15 levels represent a general...

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Share to Cyclin-Dependent Kinase Inhibitor p15
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diagnosis, Differential

Share to Melanocytes

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Share to Nevus, Pigmented

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Source

Open in PubMed Open full text

Identifiers

PMID: 27855847
DOI: 10.1016/j.ajpath.2016.08.009
PMCID: PMC5225287

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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