Depletion of growth differentiation factor 15 ( GDF15 ) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts

Abstract excerpt

Growth differentiation factor 15 (GDF15) is a stress-responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence-associated secretory phenotype. Fibroblast-specific...

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