Article

Distinct senescence mechanisms restrain progression of dysplastic nevi

2023-07-16

Abstract excerpt

TERT promoter mutations (TPMs) are frequently found in different cancer types, including approximately 70% of sun-exposed skin melanomas. In melanoma, TPMs are among the earliest mutations and can be present during the transition from nevus to melanoma. However, the specific factors that contribute to the selection of TPMs in certain nevi subsets are not well understood. To investigate this, we analyzed a group of...

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Literature Corpus work: 75c373eb-46f5-5f42-9586-f9b3942c4f7b
DOI: 10.1101/2023.07.14.548818

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