Article
Nevus Size and Number Are Associated with Telomere Length and Represent Potential Markers of a Decreased Senescence <i>In vivo</i>
1 Jul 2007
Abstract excerpt
Nevus counts represent one of the strongest risk factors for melanoma. They appear in childhood and adolescence and involute from middle age onwards. Recent evidence has shown that nevus cells undergo oncogene-induced senescence involving the p16/retinoblastoma pathway. However, telomere length also influences senescence in proliferative somatic cells and varies between individuals. This study explores whether...
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