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Article

Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage.

Journal of bone and mineral metabolism - 1 Nov 2017

Janune Danilo, Abd El Kader Tarek, Aoyama Eriko, Nishida Takashi, Tabata Yasuhiko, Kubota Satoshi, Takigawa Masaharu

Abstract excerpt

Knowledge of the microenvironment of articular cartilage in health and disease is the key to accomplishing fundamental disease-modifying treatments for osteoarthritis. The proteins comprising the CCN Family are matricellular proteins with a remarkable relevance within the context of cartilage metabolism. CCN2 displays a great capability for regenerating articular cartilage, and CCN3 has been shown to activate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27853940
DOI: 10.1007/s00774-016-0793-4

Genes

CCN3
MIA
CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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