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Article

Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes.

The FEBS journal - 1 Oct 2012

Hoshijima Mitsuhiro, Hattori Takako, Aoyama Eriko, Nishida Takashi, Yamashiro Takashi, Takigawa Masaharu

Abstract excerpt

To identify proteins that regulate CCN2 activity, we carried out GAL4-based yeast two-hybrid screening with a cDNA library derived from a chondrocytic cell line, HCS-2/8. CCN2/CTGF and CCN3/NOV polypeptides were picked up as CCN2-binding proteins, and CCN2–CCN2 and CCN2–CCN3 binding domains were identified. Direct binding between CCN2 and CCN3 was confirmed by coimmunoprecipitation in vitro and in vivo and...

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Source

Identifiers

PMID: 22812570
DOI: 10.1111/j.1742-4658.2012.08717.x

Genes

CCN2
CCN3
ACAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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