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Article

Epigenomic Deconvolution of Breast Tumors Reveals Metabolic Coupling between Constituent Cell Types.

Cell reports - 15 Nov 2016

Onuchic Vitor, Hartmaier Ryan J, Boone David N, Samuels Michael L, Patel Ronak Y, White Wendy M, Garovic Vesna D, Oesterreich Steffi, Roth Matt E, Lee Adrian V, Milosavljevic Aleksandar

Abstract excerpt

Cancer progression depends on both cell-intrinsic processes and interactions between different cell types. However, large-scale assessment of cell type composition and molecular profiles of individual cell types within tumors remains challenging. To address this, we developed epigenomic deconvolution (EDec), an in silico method that infers cell type composition of complex tissues as well as DNA methylation and...

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Identifiers

PMID: 27851969
DOI: 10.1016/j.celrep.2016.10.057
PMCID: PMC5115176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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