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Article

Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects.

Autophagy - 2 Jan 2017

Callegari Sylvie, Oeljeklaus Silke, Warscheid Bettina, Dennerlein Sven, Thumm Michael, Rehling Peter, Dudek Jan

Abstract excerpt

The E3 ubiquitin ligase PARK2 and the mitochondrial protein kinase PINK1 are required for the initiation of mitochondrial damage-induced mitophagy. Together, PARK2 and PINK1 generate a phospho-ubiquitin signal on outer mitochondrial membrane proteins that triggers recruitment of the autophagy machinery. This paper describes the detection of a defined 500-kDa phospho-ubiquitin-rich PARK2 complex that accumulates...

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Source

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Identifiers

PMID: 27846363
DOI: 10.1080/15548627.2016.1254852
PMCID: PMC5240832

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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