Article

Endosomes facilitate mitochondrial clearance by enhancing Parkin recruitment to mitochondria

2020-02-19

Abstract excerpt

Mutations in ubiquitin ligase Parkin are associated with Parkinson’s disease and defective mitophagy. Conceptually, Parkin-dependent mitophagy is classified into two phases; 1. Parkin recruits to and ubiquitinates mitochondrial proteins, 2. Formation of autophagosome membrane, sequestering mitochondria for degradation. Recently, endosomal machineries were reported to contribute to the later stage for membrane asse...

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Literature Corpus work: 641ae409-4642-52b1-95d8-d70abfbfd3fa
DOI: 10.1101/2020.02.19.955880

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