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Article

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

2 Jan 2011

Abstract excerpt

Mitochondria, which convert energy for the cell, accumulate damage with age, and the resulting mitochondrial dysfunction has been linked to the development of degenerative diseases and aging. To curb the accumulation of damaged mitochondria, the cell has elaborated a number of mitochondrial quality control processes. We describe recent work suggesting that Parkin and PTEN-induced putative kinase 1 (PINK1), two...

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Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
Share to Parkinson's Disease Mechanisms and Treatments

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Identifiers

PMID: 21194381
DOI: 10.1089/ars.2010.3799

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