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Article

Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis.

Disease models & mechanisms - 1 Feb 2017

Lin Wei-Hsiang, Giachello Carlo N G, Baines Richard A

Abstract excerpt

Epilepsy is a significant disorder for which approximately one-third of patients do not respond to drug treatments. Next-generation drugs, which interact with novel targets, are required to provide a better clinical outcome for these individuals. To identify potential novel targets for antiepileptic drug (AED) design, we used RNA sequencing to identify changes in gene transcription in two seizure models of the...

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Anticonvulsants
Epilepsy
Homeostasis
Motor Neurons
RNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, RNA

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Identifiers

PMID: 28067623
DOI: 10.1242/dmm.027045
PMCID: PMC5312004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis.PMID 28067623Read ↗

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