Article
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.
Cellular signalling - 1 Jan 2017
Schäfer Claudia, Göder Anja, Beyer Mandy, Kiweler Nicole, Mahendrarajah Nisintha, Rauch Anke, Nikolova Teodora, Stojanovic Natasa, Wieczorek Martin, Reich Thomas R, Tomicic Maja T, Linnebacher Michael, Sonnemann Jürgen, Dietrich Sascha, Sellmer Andreas, Mahboobi Siavosh, Heinzel Thorsten, Schneider Günter, Krämer Oliver H
Abstract excerpt
The transcription factors NF-κB and p53 as well as their crosstalk determine the fate of tumor cells upon therapeutic interventions. Replicative stress and cytokines promote signaling cascades that lead to the co-regulation of p53 and NF-κB. Consequently, nuclear p53/NF-κB signaling complexes activate NF-κB-dependent survival genes. The 18 histone deacetylases (HDACs) are epigenetic modulators that fall into four...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.