Article
Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8.
Oncogene - 31 Jan 2013
Yan W, Liu S, Xu E, Zhang J, Zhang Y, Chen X, Chen X
Abstract excerpt
Mutation of the p53 gene is the most common genetic alteration in human cancer and contributes to malignant process by enhancing transformed properties of cells and resistance to anticancer therapy. Mutant p53 is often highly expressed in tumor cells at least, in part, due to its increased half-life. However, whether mutant p53 expression is regulated by other mechanisms in tumors is unclear. Here we found that...
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