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Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes

13 Jan 2020

Abstract excerpt

PURPOSE: We set out to determine whether clinically tested epigenetic drugs against class I histone deacetylases (HDACs) affect hallmarks of the metastatic process. METHODS: We treated permanent and primary renal, lung, and breast cancer cells with the class I histone deacetylase inhibitors (HDACi) entinostat (MS-275) and valproic acid (VPA), the replicative stress inducer hydroxyurea (HU), the DNA-damaging agent...

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PMID: 31932908
DOI: 10.1007/s00432-019-03118-4

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