Article
Using whole-genome sequences of the LG/J and SM/J inbred mouse strains to prioritize quantitative trait genes and nucleotides.
BMC genomics - 28 May 2015
Nikolskiy Igor, Conrad Donald F, Chun Sung, Fay Justin C, Cheverud James M, Lawson Heather A
Abstract excerpt
BACKGROUND: The laboratory mouse is the most commonly used model for studying variation in complex traits relevant to human disease. Here we present the whole-genome sequences of two inbred strains, LG/J and SM/J, which are frequently used to study variation in complex traits as diverse as aging, bone-growth, adiposity, maternal behavior, and methamphetamine sensitivity. RESULTS: We identified small nucleotide...
Topics
- Algorithms
- Animals
- Disease Models, Animal
- Evolution, Molecular
- Genetic Variation
- Genome
- Mice
- Mice, Inbred Strains
- Phylogeny
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Sequence Analysis, DNA