Article
Oncogenic mutation in RAS-RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer.
Cancer science - 1 Oct 2020
Kochi Masatoshi, Hinoi Takao, Niitsu Hiroaki, Miguchi Masashi, Saito Yasufumi, Sada Haruki, Sentani Kazuhiro, Sakamoto Naoya, Oue Naohide, Tashiro Hirotaka, Sotomaru Yusuke, Yasui Wataru, Ohdan Hideki
Abstract excerpt
BRAFV600E mutation accounts for up to 90% of all BRAF mutations in human colorectal cancer (CRC), and constitutively activates the MEK-MAPK pathway. It is recognized that neutralizing mAbs for epidermal growth factor receptor alone are not effective for CRC with BRAFV600E mutation. Therefore, there is increasing interest in identification of the possible therapeutic targets in downstream of BRAF mutation in CRCs....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.