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Article

KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer.

Oncotarget - 6 Dec 2016

Cho Yong-Hee, Cha Pu-Hyeon, Kaduwal Saluja, Park Jong-Chan, Lee Sang-Kyu, Yoon Jeong-Soo, Shin Wookjin, Kim Hyuntae, Ro Eun Ji, Koo Kyung-Hwa, Park Ki-Sook, Han Gyoonhee, Choi Kang-Yell

Abstract excerpt

APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. In addition, both β-catenin and Ras levels are highly increased in CRC, especially in metastatic CRC (mCRC). Therefore, targeting both the Wnt/β-catenin and Ras pathways could be an ideal therapeutic approach for treating mCRC patients. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27835580
DOI: 10.18632/oncotarget.13172
PMCID: PMC5348425

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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