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Article

Zebrafish Model for Functional Screening of Flow-Responsive Genes.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2017

Serbanovic-Canic Jovana, de Luca Amalia, Warboys Christina, Ferreira Pedro F, Luong Le A, Hsiao Sarah, Gauci Ismael, Mahmoud Marwa, Feng Shuang, Souilhol Celine, Bowden Neil, Ashton John-Paul, Walczak Henning, Firmin David, Krams Rob, Mason Justin C, Haskard Dorian O, Sherwin Spencer, Ridger Victoria, Chico Timothy J A, Evans Paul C

Abstract excerpt

OBJECTIVE: Atherosclerosis is initiated at branches and bends of arteries exposed to disturbed blood flow that generates low shear stress. This mechanical environment promotes lesions by inducing endothelial cell (EC) apoptosis and dysfunction via mechanisms that are incompletely understood. Although transcriptome-based studies have identified multiple shear-responsive genes, most of them have an unknown...

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Gene Knockdown Techniques

Share to Mechanotransduction, Cellular

Share to Regional Blood Flow

Share to Stress, Mechanical

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Source

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Identifiers

PMID: 27834691
DOI: 10.1161/ATVBAHA.116.308502
PMCID: PMC5172514

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PERP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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