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Article

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Ceneri Nicolle, Zhao Lina, Young Bryan D, Healy Abigail, Coskun Suleyman, Vasavada Hema, Yarovinsky Timur O, Ike Kenneth, Pardi Ruggero, Qin Lingfen, Qin Li, Tellides George, Hirschi Karen, Meadows Judith, Soufer Robert, Chun Hyung J, Sadeghi Mehran M, Bender Jeffrey R, Morrison Alan R

Abstract excerpt

OBJECTIVE: The calcium composition of atherosclerotic plaque is thought to be associated with increased risk for cardiovascular events, but whether plaque calcium itself is predictive of worsening clinical outcomes remains highly controversial. Inflammation is likely a key mediator of vascular calcification, but immune signaling mechanisms that promote this process are minimally understood. APPROACH AND RESULTS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin 1 Receptor Antagonist Protein

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Source

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Identifiers

PMID: 27834690
DOI: 10.1161/ATVBAHA.116.308507
PMCID: PMC5269510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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