Article
High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma.
Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 2016
Yoshikawa Yoshie, Emi Mitsuru, Hashimoto-Tamaoki Tomoko, Ohmuraya Masaki, Sato Ayuko, Tsujimura Tohru, Hasegawa Seiki, Nakano Takashi, Nasu Masaki, Pastorino Sandra, Szymiczek Agata, Bononi Angela, Tanji Mika, Pagano Ian, Gaudino Giovanni, Napolitano Andrea, Goparaju Chandra, Pass Harvey I, Yang Haining, Carbone Michele
Abstract excerpt
We used a custom-made comparative genomic hybridization array (aCGH; average probe interval 254 bp) to screen 33 malignant mesothelioma (MM) biopsies for somatic copy number loss throughout the 3p21 region (10.7 Mb) that harbors 251 genes, including BRCA1 (breast cancer 1)-associated protein 1 (BAP1), the most commonly mutated gene in MM. We identified frequent minute biallelic deletions (<3 kb) in 46 of 251...
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