Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptotic mechanisms in mutant LRRK2-mediated cell death

4 Apr 2007

Abstract excerpt

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) cause autosomal-dominant Parkinson's disease. The pathological mutations have been associated with an increase of LRRK2 kinase activity, although its physiological substrates have not been identified yet. The data we report here demonstrate that disease-associated mutant LRRK2 cell toxicity is due to mitochondria-dependent apoptosis. Transient...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Parkinson's Disease Mechanisms and Treatments
Share to Plant Gene Expression Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17409193
DOI: 10.1093/hmg/ddm080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptotic mechanisms in mutant LRRK2-mediated cell deathPMID 17409193Read ↗

The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of NeurodegenerationSemantic proximity Read ↗

Neuronal death signaling pathways triggered by mutant LRRK2.Semantic proximity Read ↗

LRRK2 signaling pathways: the key to unlocking neurodegeneration?Semantic proximity Read ↗

Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.Semantic proximity Read ↗

A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathwaySemantic proximity Read ↗

LRRK2 variant associated with Alzheimer's disease.Semantic proximity Read ↗

LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives.Semantic proximity Read ↗

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity.Semantic proximity Read ↗

[Apoptosis of peripheral blood lymphocytes in patients with LRRK2-assoctated Parkinson's disease].Semantic proximity Read ↗

LRRK2 Knockout Confers Resistance in HEK-293 Cells to Rotenone-Induced Oxidative Stress, Mitochondrial Damage, and ApoptosisSemantic proximity Read ↗

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.Semantic proximity Read ↗

Apoptosis in amyotrophic lateral sclerosis: a review of the evidenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.