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Article

ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells.

Cell death & disease - 10 Nov 2016

Cai Jianye, Wang Jiancheng, Huang Yinong, Wu Haoxiang, Xia Ting, Xiao Jiaqi, Chen Xiaoyong, Li Hongyu, Qiu Yuan, Wang Yingnan, Wang Tao, Xia Huimin, Zhang Qi, Xiang Andy Peng

Abstract excerpt

The bone marrow microenvironment facilitates the proliferation and survival of leukemia cells, contributing to disease relapse. Bone marrow-derived mesenchymal stem cells (MSCs) are well known to promote cancer chemoresistance via soluble factors and cell adhesion. However, little is known about the effects of MSCs on the mitochondrial dynamics of T-cell acute lymphoblastic leukemia (T-ALL) cells, or how this may...

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Identifiers

PMID: 27831567
DOI: 10.1038/cddis.2016.370
PMCID: PMC5260898

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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