Article
Trans-ethnic follow-up of breast cancer GWAS hits using the preferential linkage disequilibrium approach.
Oncotarget - 13 Dec 2016
Zhu Qianqian, Shepherd Lori, Lunetta Kathryn L, Yao Song, Liu Qian, Hu Qiang, Haddad Stephen A, Sucheston-Campbell Lara, Bensen Jeannette T, Bandera Elisa V, Rosenberg Lynn, Liu Song, Haiman Christopher A, Olshan Andrew F, Palmer Julie R, Ambrosone Christine B
Abstract excerpt
Leveraging population-distinct linkage equilibrium (LD) patterns, trans-ethnic follow-up of variants discovered from genome-wide association studies (GWAS) has proved to be useful in facilitating the identification of bona fide causal variants. We previously developed the preferential LD approach, a novel method that successfully identified causal variants driving the GWAS signals within European-descent...
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