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Article

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

26 Jul 2018

Abstract excerpt

Abstract Necroptosis complements apoptosis as a host defense pathway to stop virus infection. Herpes simplex virus shows a propensity to trigger necroptosis of mouse cells and mice even though cell death is blocked in human cells through UL39-encoded ICP6. This ribonucleotide reductase large subunit (R1) nucleates RHIM-dependent oligomerization of RIP3 kinase (RIPK3, also known as RIP3) in mouse cells but...

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Identifiers

PMID: 30050136
DOI: 10.1038/s41419-018-0868-3

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