Article
GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.
The Journal of investigative dermatology - 1 Mar 2017
Pierre Sandra, Linke Bona, Suo Jing, Tarighi Neda, Del Turco Domenico, Thomas Dominique, Ferreiros Nerea, Stegner David, Frölich Stefanie, Sisignano Marco, Meyer Dos Santos Sascha, deBruin Natasja, Nüsing Rolf M, Deller Thomas, Nieswandt Bernhard, Geisslinger Gerd, Scholich Klaus
Abstract excerpt
Platelets are well known for their role in hemostasis but are also increasingly recognized for their supporting role in innate immune responses. Here, we studied the role of platelets in the development of peripheral inflammation and found that platelets colocalize with macrophages in the inflamed tissue outside of blood vessels in different animal models for cutaneous inflammation. Collagen-treatment of...
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