Article
PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo.
Science advances - 1 Sept 2018
Loynes Catherine A, Lee Jou A, Robertson Anne L, Steel Michael Jg, Ellett Felix, Feng Yi, Levy Bruce D, Whyte Moira K B, Renshaw Stephen A
Abstract excerpt
Neutrophils are the first immune cells recruited to a site of injury or infection, where they perform many functions. Having completed their role, neutrophils must be removed from the inflammatory site-either by apoptosis and efferocytosis or by reverse migration away from the wound-for restoration of normal tissue homeostasis. Disruption of these tightly controlled physiological processes of neutrophil removal...
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