Article
Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility-Mass Spectrometry: Lessons from a Collection of Representatives.
Journal of the American Society for Mass Spectrometry - 1 Feb 2017
Fouque Kevin Jeanne Dit, Lavanant Hélène, Zirah Séverine, Hegemann Julian D, Zimmermann Marcel, Marahiel Mohamed A, Rebuffat Sylvie, Afonso Carlos
Abstract excerpt
Lasso peptides are characterized by a mechanically interlocked structure, where the C-terminal tail of the peptide is threaded and trapped within an N-terminal macrolactam ring. Their compact and stable structures have a significant impact on their biological and physical properties and make them highly interesting for drug development. Ion mobility - mass spectrometry (IM-MS) has shown to be effective to...
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