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Ion Mobility–Enhanced Liquid Chromatography Coupled with Mass Spectrometry (LC–MS) Enables Reliable Detection of OXA-48-Like Carbapenemases Beyond Conventional Activity-Based Assays

2026-04-02

Abstract excerpt

Carbapenemases are major drivers of carbapenem resistance in Gram-negative bacteria and pose a critical threat to last-line antibiotic therapy. Rapid identification of carbapenemase classes is essential for appropriate treatment and epidemiological surveillance; however, current functional methods lack class-level resolution and may yield false-negative results for OXA-48-like enzymes. In this study, we developed...

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Literature Corpus work
e56dc365-51a6-55f1-8cca-c3e696dc2683
DOI
10.64898/2026.03.30.715343
Open publication

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Ion Mobility–Enhanced Liquid Chromatography Coupled with Mass Spectrometry (LC–MS) Enables Reliable Detection of OXA-48-Like Carbapenemases Beyond Conventional Activity-Based AssaysDOI 10.64898/2026.03.30.715343
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