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Article

Type I interferon suppresses virus-specific B cell responses by modulating CD8 + T cell differentiation

21 Oct 2016

Abstract excerpt

T cell response. Using two-photon microscopy and in vivo calcium imaging, we observed that cytotoxic T lymphocytes (CTLs) productively engaged and killed LCMV-specific B cells in a perforin-dependent manner within the first few days of infection. Blockade of IFN-I signaling protected LCMV-specific B cells by promoting CTL dysfunction. Therapeutic manipulation of this pathway may facilitate efforts to promote...

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PMID: 27812556
DOI: 10.1126/sciimmunol.aah3565

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