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Article

Cumulative effect of the plasma total homocysteine-related genetic variants on schizophrenia risk.

Psychiatry research - 30 Dec 2016

Kinoshita Makoto, Numata Shusuke, Tajima Atsushi, Nishi Akira, Muraki Sho, Tsuchiya Atsushi, Umehara Hidehiro, Watanabe Shin-Ya, Imoto Issei, Ohmori Tetsuro

Abstract excerpt

Previous studies suggest that elevated total homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which correlates with plasma total homocysteine levels, are risk factors for schizophrenia (SCZ). Recently, a large genome-wide association study (GWAS) of plasma total homocysteine levels in individuals of European ancestry identified many single-nucleotide polymorphisms (SNPs)...

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Source

Identifiers

PMID: 27810229
DOI: 10.1016/j.psychres.2016.10.017

Genes

MTHFR
CENPQ
CPS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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