Article
RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking.
The FEBS journal - 1 Dec 2016
Deshar Rakesh, Moon Song, Yoo Wonjin, Cho Eun-Bee, Yoon Sungjoo K, Yoon Jong-Bok
Abstract excerpt
The protease-associated (PA) domain-containing E3 ubiquitin ligases are transmembrane proteins located in intracellular organelles such as the endoplasmic reticulum, endosomes, or lysosomes. The functional roles of these ubiquitin ligases are not well defined. To understand the function of E3 ubiquitin ligases, identification of their substrates is of critical importance. In this study, we describe a newly...
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