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Article

BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.

Cell reports - 15 Nov 2016

Guardia Carlos M, Farías Ginny G, Jia Rui, Pu Jing, Bonifacino Juan S

Abstract excerpt

The multiple functions of lysosomes are critically dependent on their ability to undergo bidirectional movement along microtubules between the center and the periphery of the cell. Centrifugal and centripetal movement of lysosomes is mediated by kinesin and dynein motors, respectively. We recently described a multi-subunit complex named BORC that recruits the small GTPase Arl8 to lysosomes to promote their...

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Identifiers

PMID: 27851960
DOI: 10.1016/j.celrep.2016.10.062
PMCID: PMC5136296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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