The extracellular matrix protein laminin α2 regulates the maturation and function of the blood-brain barrier.

Abstract excerpt

Laminins are major constituents of the gliovascular basal lamina of the blood-brain barrier (BBB); however, the role of laminins in BBB development remains unclear. Here we report that Lama2(-/-) mice, lacking expression of the laminin α2 subunit of the laminin-211 heterotrimer expressed by astrocytes and pericytes, have a defective BBB in which systemically circulated tracer leaks into the brain parenchyma. The...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigens, Surface
• Share to Aquaporin 4