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Article

Vascular development of the brain requires beta8 integrin expression in the neuroepithelium.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Oct 2005

Proctor John M, Zang Keling, Wang Denan, Wang Rong, Reichardt Louis F

Abstract excerpt

We showed previously that loss of the integrin beta8 subunit, which forms alphavbeta8 heterodimers, results in abnormal vascular development in the yolk sac, placenta, and brain. Animals lacking the integrin beta8 (itgbeta8) gene die either at midgestation, because of insufficient vascularization of the placenta and yolk sac, or shortly after birth with severe intracerebral hemorrhage. To specifically focus on...

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Identifiers

PMID: 16251442
DOI: 10.1523/JNEUROSCI.3467-05.2005
PMCID: PMC2849654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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