Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.

The Journal of cell biology - 22 Jul 2013

Chen Zu-Lin, Yao Yao, Norris Erin H, Kruyer Anna, Jno-Charles Odella, Akhmerov Akbarshakh, Strickland Sidney

Abstract excerpt

Astrocytes express laminin and assemble basement membranes (BMs) at their endfeet, which ensheath the cerebrovasculature. The function of astrocytic laminin in cerebrovascular integrity is unknown. We show that ablation of astrocytic laminin by tissue-specific Cre-mediated recombination disrupted endfeet BMs and led to hemorrhage in deep brain regions of adult mice, resembling human hypertensive hemorrhage. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arterioles
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Basement Membrane

Share to Laminin

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Myosin Heavy Chains

Share to Platelet Endothelial Cell Adhesion Molecule-1

Source

Open in PubMed Open full text

Identifiers

PMID: 23857767
DOI: 10.1083/jcb.201212032
PMCID: PMC3718965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ablation of astrocytic laminin impairs vascular smooth muscle cell function and leads to hemorrhagic stroke.PMID 23857767Read ↗

The importance of laminin at the blood-brain barrierSemantic proximity Read ↗

The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.Semantic proximity Read ↗

HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel diseaseSemantic proximity Read ↗

Perturbations of the cerebrovascular matrisome: A convergent mechanism in small vessel disease of the brain?Semantic proximity Read ↗

Chronic alcohol exposure induces cerebral microbleeds by TGF-β1/Smad signaling pathway mediated remodeling of cerebral small vesselsSemantic proximity Read ↗

Involvement of aquaporin‐4 in laminin‐enhanced process formation of mouse astrocytes in 2D culture: Roles of dystroglycan and α‐syntrophin in aquaporin‐4 expressionSemantic proximity Read ↗

The role of pericytic laminin in blood brain barrier integrity maintenance.Semantic proximity Read ↗

Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.Semantic proximity Read ↗

Disrupted astrocyte-endothelial crosstalk drives hemangioblastoma lesions in VHL diseaseSemantic proximity Read ↗

Endothelial cell‐derived bone morphogenetic proteins regulate glial differentiation of cortical progenitorsSemantic proximity Read ↗

The extracellular matrix protein laminin α2 regulates the maturation and function of the blood-brain barrier.Semantic proximity Read ↗

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.