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Article

Genotype-stratified Default Mode Network hyperconnectivity in major depressive disorder: an MR imaging genetics study.

Journal of affective disorders - 15 Aug 2026

Singh Paramdeep, Singh Sandeep, Peer Sameer, Ludhiadch Abhilash, Singh Jawahar, Kaur Harmeet, Munshi Anjana

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is a prevalent and debilitating psychiatric condition defined by complex genetic and neurobiological underpinnings. The current study investigated the genetic variants associated with the disease and impact of significant variants on neurotransmitter pathways and their association with inherent brain connectivity patterns in MDD. METHODS: A total of 69 patients...

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Identifiers

PMID: 41956213
DOI: 10.1016/j.jad.2026.121751

Genes

DAOA
TPH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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