Article
Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways.
PloS one - 1 Jan 2012
deLeon Orlando, Puglise Jason M, Liu Fengming, Smits Jos, ter Beest Martin B, Zegers Mirjam M
Abstract excerpt
The development of the basic architecture of branching tubules enclosing a central lumen that characterizes most epithelial organs crucially depends on the apico-basolateral polarization of epithelial cells. Signals from the extracellular matrix control the orientation of the apical surface, so that it faces the lumen interior, opposite to cell-matrix adhesion sites. This orientation of the apical surface is...
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