Article

Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1

2022-04-18

Abstract excerpt

Feingold syndrome type 1, caused by loss-of-function of MYCN, is characterized by varied phenotypes including esophageal and duodenal atresia. However, no adequate model exists for studying the syndrome’s pathological or molecular mechanisms, nor is there a treatment strategy. Here, we developed a zebrafish Feingold syndrome type 1 model with nonfunctional mycn , which had severe intestinal atresia. Single-cell R...

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Literature Corpus work: 5bf503b1-6050-5cd7-895a-8fc6a1d3b896
DOI: 10.1101/2022.04.18.488635

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