Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atypical Forms of Congenital Hyperinsulinism in Infancy Are Associated With Mosaic Patterns of Immature Islet Cells.

The Journal of clinical endocrinology and metabolism - 1 Sept 2017

Han Bing, Mohamed Zainab, Estebanez Maria Salomon, Craigie Ross J, Newbould Melanie, Cheesman Edmund, Padidela Raja, Skae Mars, Johnson Matthew, Flanagan Sarah, Ellard Sian, Cosgrove Karen E, Banerjee Indraneel, Dunne Mark J

Abstract excerpt

Objectives: We aimed to characterize mosaic populations of pancreatic islet cells from patients with atypical congenital hyperinsulinism in infancy (CHI-A) and the expression profile of NKX2.2, a key transcription factor expressed in β-cells but suppressed in δ-cells in the mature pancreas. Patients/Methods: Tissue was isolated from three patients with CHI-A following subtotal pancreatectomy. CHI-A was diagnosed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy, Needle
Share to Congenital Hyperinsulinism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Islets of Langerhans

Share to Mosaicism

Share to Pancreatectomy

Share to Reference Values

Share to Thyroid Nuclear Factor 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28605545
DOI: 10.1210/jc.2017-00158
PMCID: PMC5587070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atypical Forms of Congenital Hyperinsulinism in Infancy Are Associated With Mosaic Patterns of Immature Islet Cells.PMID 28605545Read ↗

Altered Phenotype of β-Cells and Other Pancreatic Cell Lineages in Patients With Diffuse Congenital Hyperinsulinism in Infancy Caused by Mutations in the ATP-Sensitive K-Channel.Semantic proximity Read ↗

Morphological mosaicism of the pancreatic islets: a novel anatomopathological form of persistent hyperinsulinemic hypoglycemia of infancy.Semantic proximity Read ↗

Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin productionSemantic proximity Read ↗

Hyperinsulinism in infancy: understanding the pathophysiology.Semantic proximity Read ↗

The focal form of persistent hyperinsulinemic hypoglycemia of infancy: morphological and molecular studies show structural and functional differences with insulinoma.Semantic proximity Read ↗

Genotype-histotype-phenotype correlations in hyperinsulinemic hypoglycemia.Semantic proximity Read ↗

Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periodsSemantic proximity Read ↗

CD81 marks immature and dedifferentiated pancreatic β-cellsSemantic proximity Read ↗

Persistent hyperinsulinemic hypoglycemia of infancy.Semantic proximity Read ↗

Localized islet nuclear enlargement hyperinsulinism (LINE-HI) due to ABCC8 and GCK mosaic mutations.Semantic proximity Read ↗

Genotype-phenotype associations in patients with severe hyperinsulinism of infancy.Semantic proximity Read ↗

Alterations in Beta Cell Identity in Type 1 and Type 2 DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.